Roberttanser
165 posts
Jul 23, 2024
11:24 PM
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Fildena 150 mg contains sildenafil, which is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It is crucial to avoid using Fildena 150 mg with nitrates due to the following reasons:
Interaction Between Sildenafil and Nitrates:
Mechanism of Interaction:
Sildenafil's Effect: Sildenafil works by inhibiting PDE5, which leads to an increase in cyclic GMP (cGMP) in the smooth muscles of the penis. This causes relaxation of the smooth muscles and increased blood flow, leading to an erection.
Nitrates' Effect: Nitrates, commonly used to treat angina (chest pain) and other heart conditions, work by releasing nitric oxide (NO) in the body. NO increases cGMP in smooth muscles, which causes relaxation and dilation of blood vessels to relieve chest pain.
Additive Effect on cGMP:
Enhanced cGMP Levels: Both sildenafil and nitrates increase the levels of cGMP in the body. When taken together, they can cause an excessive accumulation of cGMP, leading to a significant drop in blood pressure.
Risk of Severe Hypotension:
Low Blood Pressure: The combined effect of sildenafil and nitrates can cause a profound drop in blood pressure (severe hypotension). This can lead to symptoms such as dizziness, fainting, blurred vision, and even shock in extreme cases.
Recommendations:
Avoid Concurrent Use:
Separate Use: It is crucial to avoid taking Fildena 150 Mg or any sildenafil-containing medication with nitrates. This includes both prescription nitrates and some over-the-counter products that may contain nitrates.
Consult Healthcare Provider:
Disclose All Medications: Always inform your healthcare provider about all the medications you are taking, including nitrates and any other treatments for cardiovascular conditions. Your healthcare provider can provide guidance on safe and effective alternatives.
Emergency Situations:
Seek Immediate Help: If you experience symptoms of severe hypotension or any adverse reactions after taking sildenafil and nitrates, seek immediate medical attention.
Summary:
The primary concern with using Fildena 150 mg (or any sildenafil) with nitrates is the risk of severe hypotension due to the additive effects on cGMP levels, leading to dangerously low blood pressure. To avoid these serious complications, it is essential to avoid combining these medications and consult with a healthcare provider for safe treatment options.
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