Gemini Smith
7 posts
Sep 23, 2024
9:38 PM
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Check our Nitric Oxide in IgA Synthesis
Nitric oxide (NO) is a free radical molecule that is involved in the manufacture of intestinal immunoglobulin A (IgA) and is expressed in certain dendritic cells (DCs) and associated intestinal cells. Three distinct isoforms of NO synthase (NOS) synthesis it from L-arginine: NOS1 encodes neuronal NOS, NOS2 encodes inducible NOS (iNOS), and NOS3 encodes endothelial NOS. NO acts via two pathways: heme iron- and S-nitrosylation, and it possesses neurotransmitter, immunomodulator, and vasodilator qualities. Soluble guanylate cyclase (sGC), which in turn transforms guanosine monophosphate (GMP) into cyclic GMP, a second messenger that triggers protein kinase G, is activated by NO in the heme iron route. Through the S-nitrosylation of the cysteine in the S-nitrosylation pathway, NO regulates the activity of several intracellular signaling molecules, such as transcription factors and enzymes.
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