Tadarise 5 mg, like other medications containing tadalafil (the active ingredient), can interact with grapefruit. Grapefruit and grapefruit juice can inhibit the activity of certain enzymes in the liver, particularly cytochrome P450 3A4 (CYP3A4), which is involved in metabolizing tadalafil.

When grapefruit is consumed while taking Tadarise 5 mg, it can increase the levels of tadalafil in your bloodstream, potentially leading to an increased risk of side effects, such as dizziness, headache, low blood pressure, or prolonged erections. This interaction can make the medication more potent than intended, which might not be safe.

It's generally recommended to avoid grapefruit and grapefruit juice while taking Tadarise or similar medications unless advised otherwise by your healthcare provider. If you're unsure, it's always a good idea to consult your doctor or pharmacist for personalized advice.